Marisa Arna

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In this Overview we characterise the remodelling processes in atherosclerosis, vascular and myocardial ischaemia-reperfusion injury, and coronary heart failure, and we draw consideration to potential avenues for innovative therapeutic approaches, together with conditioning and metabolic strategies.

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Fukushima, A. & Lopaschuk, G. D. Acetylation control of cardiac fatty acid beta-oxidation and vitality metabolism in weight problems, diabetes, and coronary heart failure. Remarkably, some of the uncovered expression modifications counsel an artificial fibroblast phenotype characterised by the aberrant expression of extracellular matrix (ECM) proteins.

Fibroblasts are the cells that synthesize collagenous fibres of tissues whereas myofibroblasts are muscle-like cells with energetic contractile properties sixty one Although fibroblasts exist in any type of tissue, in case of inflammation, new cells are primarily directed in direction of the allergen source.

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