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These outcomes indicate that the robustness of the protein homeostasis system depends on the absence of proteins extremely susceptible to aggregation upon any kind of stress and on the presence of changes in aggregation state of regulatory mechanisms that restore protein solubility upon particular perturbations.
The useful effect of beta-blocker therapy on LV remodelling reversal has been linked to a lower of LV volumes 8, a decrease within the LVM index 8,9 and an enchancment of LV geometry as evidenced by a decrease of the sphericity index 9. Long-term angiotensin-changing enzyme inhibition, angiotensin receptor blockade and aldosterone receptor antagonism affect LV remodelling by means of decreasing the loading conditions and cardiac afterload, resulting in an improvement in LVM and LV geometry.
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