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Pre-school children with severe wheezing that developed asthma only had significantly extra ASM in their endobronchial biopsies at pre-faculty age compared with those wheezers that did not develop asthma, whereas tissue eosinophilia or RBM thickness weren’t predictors 36 As well as, increased ASM was the only change related to atopy in extreme pre-faculty wheezers 31 Thus, early abnormalities in ASM function may determine bronchial asthma development.

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Mitral regurgitation (MR) is probably the most frequent clinically recognisable valvular coronary heart disease within the western world 1. MR could be caused by main valve anatomical issues (major MR) or it may be secondary to cardiomyopathy (secondary MR, beforehand known as purposeful MR).

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