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GO analysis of the proteins that modified solubility in 2 or more stresses illuminated the important thing mechanisms concerned ( Fig 5A ). The most enriched molecular perform terms for the extra insoluble protein checklist have been proteasome-activating ATPase exercise (eighty two.6-fold enrichment), proteasome binding (36.7-fold), structural constituent of nuclear pore (35.9-fold), ATPase activator activity, (9.9-fold), warmth shock protein binding (9.8-fold) ubiquitin protein ligase binding (6.0-fold).
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