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Storage Cabinets: These storage units offer deep drawers, and adjustable cabinets are an ideal approach to store bigger tools and equipment. Items have to be in-stock on the member’s native Participating Beta Check Program Retailer to be eligible for subsequent business day delivery.
Huntington’s disease mutations lead to expansion of a polyglutamine (polyQ) sequence in Httex1 to lengths longer than 36Q, whereas the wild-sort protein is often lower than 25Q ( Duyao et al., 1993 ). PolyQ-growth causes Httex1 to become highly aggregation susceptible, which manifests as intracellular inclusion bodies as the disease progresses ( Davies et al., 1997 ; DiFiglia et al., 1997 ; Scherzinger et al., 1997 ). We and others have used transient expression constructs of Httex1 fused to fluorescent proteins as fashions for replicating important features of the illness, including protein homeostasis stress ( Arrasate et al., 2004 ; Hosp et al., 2017 ; Kim et al., 2016 ; Moily et al., 2017 ; Ramdzan et al., 2017 ). Mutant Httex1-fluorescent protein constructs progressively form massive cytosolic inclusions in cell culture over time.
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