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Huntington’s disease mutations result in enlargement of a polyglutamine (polyQ) sequence in Httex1 to lengths longer than 36Q, whereas the wild-type protein is often lower than 25Q ( Duyao et al., 1993 ). PolyQ-expansion causes Httex1 to become highly aggregation prone, which manifests as intracellular inclusion our bodies as the disease progresses ( Davies et al., 1997 ; DiFiglia et al., 1997 ; Scherzinger et al., 1997 ). We and others have used transient expression constructs of Httex1 fused to fluorescent proteins as models for replicating essential options of the illness, together with protein homeostasis stress ( Arrasate et al., 2004 ; Hosp et al., 2017 ; Kim et al., 2016 ; Moily et … Read the rest