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When Tim films his show Instrument Time, he regularly interacts with the reside studio viewers. Buildings serve several societal needs – primarily as shelter from weather, safety, dwelling space, privacy, to retailer belongings, and to comfortably reside and work.
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It has been recommended that these aggregation-susceptible proteins, which can be affected by mutations (e.g. Htt), publish-translational modifications (e.g. tau phosphorylation), or environmental modifications, lead to oversubscription of quality management sources that overloads the protein homeostasis system ( Cox et al., 2018 ). This imbalance then triggers a cascade of protein folding defects that broadly impairs proteome function.
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